Radioprotection of Mice by Hypoxia and Chemical Agents
The 30-day survival of mice irradiated while breathing 5% oxygen was compared to those irradiated while protected by combinations of hypoxia and chemical agents. Hypoxia reduced the effectiveness of radiation by a factor of 2.5. Aminopropiophenone and 5-hydroxytryptamine, both thought to operate through oxygen-dependent pathways, did not add to the protection afforded by simple hypoxia. Dimethylsulfoxide and diethyldithiocarbamate also failed to significantly increase the effectiveness of low oxygen tension. However, the thiol compounds, cysteamine, cystamine, and 5,2-aminoethylisothiuronium consistently added to the protection afforded by hypoxia. Possible reaction mechanisms involved in chemical radioprotection are discussed. (C.H.)
- Research Organization:
- Walter Reed Army Inst. of Research, Washington, D.C.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021589
- OSTI ID:
- 4727921
- Journal Information:
- Nature (London), Journal Name: Nature (London) Journal Issue: 4878 Vol. 198; ISSN 0028-0836
- Publisher:
- Nature Publishing Group
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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