SPECT assay of radiolabeled monoclonal antibodies

Technical Report · Sat Feb 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/7288347· OSTI ID:7288347

Jaszczak, R J

The accurate determination of the biodistribution of radiolabeled monoclonal antibodies (MoAbs) is important for calculation of dosimetry and evaluation of pharmacokinetic variables such as antibody dose and route of administration. The hypothesis of this application is that the biodistribution of radiolabeled monoclonal antibodies (MoAbs) can be quantitatively determined using single photon emission computed tomography (SPECT). The major thrusts during the third year include the continued development and evaluation of improved 3D SPECT acquisition and reconstruction approaches to improve quantitative imaging of radiolabeled monoclonal antibodies (MoAbs), and the implementation and evaluation of algorithms to register serial SPECT image data sets, or to register 3D SPECT images with 3D image data sets acquired from positron emission tomography (PEI) and magnetic resonance images (MRI). The research has involved the investigation of statistical models and iterative reconstruction algorithms that accurately account for the physical characteristics of the SPECT acquisition system. It is our belief that SPECT quantification can be improved by accurately modeling the physical processes such as attenuation, scatter, geometric collimator response, and other factors that affect the measured projection data.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60894
• OSTI ID: 7288347
• Report Number(s): DOE/ER/60894-3; ON: DE92019913
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
ANTIBODIES
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COLLIMATORS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MATHEMATICAL LOGIC
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NANOSEC LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
OXYGEN 15
OXYGEN ISOTOPES
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
PROGRESS REPORT
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TISSUE DISTRIBUTION
TOMOGRAPHY