SPECT assay of radiolabeled monoclonal antibodies. Third yearly progress report, September 1991--February 1992

Technical Report · Sat Feb 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/10170842· OSTI ID:10170842

Jaszczak, R J

The accurate determination of the biodistribution of radiolabeled monoclonal antibodies (MoAbs) is important for calculation of dosimetry and evaluation of pharmacokinetic variables such as antibody dose and route of administration. The hypothesis of this application is that the biodistribution of radiolabeled monoclonal antibodies (MoAbs) can be quantitatively determined using single photon emission computed tomography (SPECT). The major thrusts during the third year include the continued development and evaluation of improved 3D SPECT acquisition and reconstruction approaches to improve quantitative imaging of radiolabeled monoclonal antibodies (MoAbs), and the implementation and evaluation of algorithms to register serial SPECT image data sets, or to register 3D SPECT images with 3D image data sets acquired from positron emission tomography (PEI) and magnetic resonance images (MRI). The research has involved the investigation of statistical models and iterative reconstruction algorithms that accurately account for the physical characteristics of the SPECT acquisition system. It is our belief that SPECT quantification can be improved by accurately modeling the physical processes such as attenuation, scatter, geometric collimator response, and other factors that affect the measured projection data.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60894
• OSTI ID: 10170842
• Report Number(s): DOE/ER/60894--3; ON: DE92019913
• Country of Publication: United States
• Language: English

Related Subjects

550601
62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
COLLIMATORS
FLUORINE 18
FLUORODEOXYGLUCOSE
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MONOCLONAL ANTIBODIES
OXYGEN 15
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TISSUE DISTRIBUTION
UNSEALED RADIONUCLIDES IN DIAGNOSTICS