Decreased tumor uptake of gallium-67 in animals after whole-body irradiation. [Gamma radiation, rats]

Journal Article · Wed Feb 01 04:00:00 EST 1978 · J. Nucl. Med.; (United States)

OSTI ID:7276867

Bradley, W P; Alderson, P O; Eckelman, W C; Hamilton, R G; Weiss, J F

The mechanism of decreased Ga-67 citrate retention and serum binding after whole-body irradiation is unknown. To investigate this mechanism and to determine the effects of prior irradiation on tumor uptake of Ga-67, Sprague-Dawley rats bearing a subcutaneous Walker-256 carcinosarcoma were exposed to whole-body Co-60 irradiations of 250-1000 rads. Each animal received 10 ..mu..Ci of Ga-67 citrate intravenously 24 hr after exposure. Control animals received Ga-67 but were not irradiated. Animals were killed at 48 hr and the uptakes (percentage ID/g) in the tumor and other tissues were determined. A blood sample was also obtained to determine the serum iron, unsaturated iron-binding capacity (UIBC) and transferrin level. Tumor uptake and serum UIBC were decreased in irradiated animals, whereas serum iron levels and Ga-67 urinary excretion were increased. There was a significant correlation between the UIBC and the Ga-67 tumor uptake (r = 0.78, p < 0.001, n = 49). Transferrin levels in the irradiated group were not different from control values. The results indicate that the decreased Ga-67 retention and tumor uptake seen after whole-body irradiation are related--at least in part--to the saturation of transferrin by increased levels of circulating iron.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 7276867
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560172 -- Radiation Effects-- Nuclide Kinetics &amp; Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
EXTERNAL IRRADIATION
GALLIUM 67
GALLIUM ISOTOPES
GAMMA RADIATION
GLOBULINS
GLOBULINS-BETA
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SARCOMAS
TRANSFERRIN
UPTAKE
VERTEBRATES
WHOLE-BODY IRRADIATION