Alteration of gallium-67 distribution in tumor-bearing mice following treatment with methotrexate: concise communication

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5401219

Chilton, H M; Witcofski, R L; Watson, Jr, N E; Heise, C M

The effect of methotrexate (MTX) treatment upon 67Ga distribution was investigated. Tumor bearing mice were injected with 67Ga citrate at varying time intervals following MTX treatment administered either as a single dose or in multiple doses. Altered 67Ga distribution was observed following MTX therapy, the general pattern showing decreased levels in blood and increased uptake in bone. MTX therapy decreased 67Ga uptake in liver, tumor, and muscle. The effects of MTX are related to the dose and time interval between the administrations of MTX and 67Ga. The serum of MTX-treated mice had lower unsaturated iron-binding capacities and higher levels of unbound 67Ga. Serum iron and iron binding in rats determined 20 hr after MTX therapy showed significantly higher levels of serum iron and lower levels of 67Ga in blood, and the percent transferrin saturation was approximately 95%. These observations suggest that MTX inhibition of erythropoiesis elevates serum iron levels and decreases the availability of gallium-binding sites in serum, resulting in altered 67Ga tissue distribution.

• Research Organization: Bowman Gray School of Medicine, Winston-Salem, North Carolina
• OSTI ID: 5401219
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FORMATION
BLOOD SERUM
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ERYTHROPOIESIS
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
GLOBULINS
GLOBULINS-BETA
INTERMEDIATE MASS NUCLEI
IRON
ISOTOPES
LIVER
MAMMALS
METALLOPROTEINS
METALS
METHOTREXATE
MICE
MUSCLES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RECEPTORS
RODENTS
SKELETON
TISSUE DISTRIBUTION
TRANSFERRIN
TRANSITION ELEMENTS
VERTEBRATES