Alteration of gallium-67 distribution in tumor-bearing mice following treatment with methotrexate: concise communiction

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:5801332

Chilton, H M; Witcofski, R L; Watson, N E; Heise, C M

The effect of methotrexate (MTX) treatment upon Ga-67 distribution was investigated. Tumor bearing mice were injected with Ga-67 citrate at varying time intervals following MTX treatment administered either as a single dose or in multiple doses. Altered Ga-67 distribution was observed following MTX therapy, the general pattern showing decreased levels in blood and increased uptake in bone. MTX therapy decreased Ga-67 uptake in liver, tumor, and muscle. The effects of MTX are related to the dose and time interval between the administrations of MTX and Ga-67. The serum of MTX-treated mice had lower unsaturated iron-binding capacities and higher levels of unbound Ga-67. Serum iron and iron binding in rats determined 20 hr after MTX therapy showed significantly higher levels of serum iron and lower levels of Ga-67 in blood, and the percent transferrin saturation was approximately 95%. These observations suggest that MTX inhibition of erythropoiesis elevates serum iron levels and decreases the availability of gallium-binding sites in serum, resulting in altered Ga-67 tissue distribution.

• Research Organization: Bowman Gray School of Medicine, Winston-Salem, NC
• OSTI ID: 5801332
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BODY
CHEMOTHERAPY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIVER
MAMMALS
METHOTREXATE
MICE
MUSCLES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
THERAPY
UPTAKE
VERTEBRATES