Effect of iron deficiency on the biodistribution and tumor uptake of Ga-67 citrate in animals: concise communication

Journal Article · Thu Mar 01 04:00:00 EST 1979 · J. Nucl. Med.; (United States)

OSTI ID:5883466

Bradley, W P; Alderson, P O; Weiss, J F

To investigate the effect of iron deficiency on the biodistribution and tumor uptake of Ga-67 citrate, 20 weanling Sprague-Dawley rats were maintained for 6 to 8 weeks on a low-iron diet. Eighteen littermates were maintained on a normal iron diet and served as controls. Animals received 10 ..mu..Ci Ga-67 citrate, and urine and feces were collected for 48 h. The animals were then killed, tissue samples were obtained, and serum iron and unsaturated iron-binding capacity (UIBC) were measured. The accumulation of Ga-67 in the liver and spleen (% injected dose) was markedly increased in iron-deficient animals and urinary excretion was reduced. Tumor uptake was not significantly different in iron-deficient and control animals, but tumor-to-blood ratios were elevated (p < 0.001) in the iron-deficient animals because of low blood levels of Ga-67. The liver and spleen accumulation of Ga-67 correlated significantly (p < 0.001) with the UIBC. The results show that iron deficiency alters the distribution of Ga-67 citrate, and suggest that the variable liver-spleen uptake seen in clinical Ga-67 images may be explained, in part, by changes in serum iron and UIBC.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD
• OSTI ID: 5883466
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:3; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
CARBOXYLIC ACID SALTS
CITRATES
COMPLEXES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIET
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FECES
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
IRON
IRON COMPLEXES
ISOTOPES
LIVER
MAMMALS
MEDICINE
METALS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SCINTISCANNING
SPLEEN
SYMPTOMS
TISSUE DISTRIBUTION
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES