Carcinogenicity and DNA binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene in rainbow trout by controlled laboratory exposure

Conference · Thu Sep 01 00:00:00 EDT 1988 · Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA)

OSTI ID:7266318

Fong, A T; Hendricks, J D; Bailey, G S ^[1]

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1. Oregon State Univ., Corvallis (USA)

Polycyclic aromatic hydrocarbons (PAH) recently have been implicated as etiological agents responsible for observed neoplasia in some feral fish populations. However, establishing a direct causal relationship has not been possible in part because only a few PAH have been tested for carcinogenicity in fish models. The present studies were undertaken to characterize the carcinogenicity and DNA binding of benzo(a)pyrene (BP) and 7,12-dimethylbenz(a)anthracene (DMBA) in the rainbow trout by controlled laboratory exposure. Two parameters which may influence tumor response to PAH were examined, route of exposure and life stage at exposure. Although rainbow trout seldom inhibit polluted environments where fish tumor epizootics occur, this extensively studied fish species provides a useful model for examining the carcinogenic effects of environmental contamination because they have been shown to be highly sensitive to the carcinogenic effects of aflatoxin B{sub 1} and over 20 other carcinogens. The results of these studies show that the trout is sensitive to the carcinogenic effects of PAH at the embryo, fry, and juvenile life stages, and that tumor response and site of tumor formation depend on the particular PAH used, the dose of PAH, and the route of administration.

• OSTI ID: 7266318
• Report Number(s): CONF-8909236--
• Journal Information: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA), Journal Name: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA) Vol. 28:2; ISSN 0099-7293; ISSN ACWCA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
AGE DEPENDENCE
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
BIOSYNTHESIS
CARCINOGENESIS
CONDENSED AROMATICS
DISEASES
DNA ADDUCTS
DOSE-RESPONSE RELATIONSHIPS
FISHES
HYDROCARBONS
NEOPLASMS
ORGANIC COMPOUNDS
PATHOGENESIS
SENSITIVITY
SYNTHESIS
TOXICITY
TROUT
VERTEBRATES