Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Initiation, promotion, and inhibition of carcinogenesis in rainbow trout

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.8771147· OSTI ID:6785936
; ;
The identification of etiological agents in feral fish neoplasia epizootics has been hampered in part by the lack of suitable fish models, and complicated by the likely existence of environmental agents which can act to stimulate or reduce population responses to genotoxin insult. The response of fish to tumor inhibitors and promoters, and the underlying mechanisms of modulation, have been studied in the rainbow trout model. Dietary treatment of trout with the compounds indole-3-carbinol (I3C), ..beta..-napthroflavone (BNF), or the polychlorinated biphenyl (PCB) complex Aroclor 1254, before and during exposure to aflatoxin B/sub 1/ (AFB1), was shown to reduce the final incidence of hepatocellular carcinoma after 12 months, compared to fish receiving AFB1 only. By contrast, treatment of trout with BNF or I3C following AFB1 initiation led to a significant enhancement of ultimate tumor response, Similarly, simultaneous treatment of trout with PCB and the carcinogen N-nitrosodiethylamine led to syncarcinogenic enhancement, rather than inhibition, of tumor response. Mechanisms of inhibition of AFB1 carcinogenesis by PCB, BNF, and I3C were investigated. PCB and BNF, but not I3C, are known to be strong inducers of trout cytochrome P448 and associated activities. Dietary induction by BNF or PCB was shown to be accompanied in solvated hepatocytes by considerably altered AFB1 metabolism, and by significantly reduced rates of DNA adduct formation for all three agents. All agents differentially altered in vivo AFB1 pharmacokinetics, enhanced bile elimination of AFB1 as the aflatoxicol-M1 glucuronide, and significantly reduced peak levels of liver DNA adduct formation.
Research Organization:
Oregon State Univ., Corvallis
OSTI ID:
6785936
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 71; ISSN EVHPA
Country of Publication:
United States
Language:
English

Similar Records

Carcinogenicity and DNA binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene in rainbow trout by controlled laboratory exposure
Conference · Thu Sep 01 00:00:00 EDT 1988 · Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA) · OSTI ID:7266318
Ultraviolet irradiation of monkey cells enhances the repair of DNA adducts in alpha DNA
Journal Article · Wed Oct 31 23:00:00 EST 1984 · Carcinogenesis (N.Y.); (United States) · OSTI ID:5948408
Effect of dose on the inhibition of carcinogenesis/mutagenesis by aroclor 1254 in rainbow trout fed aflatoxin B/sub 1/
Journal Article · Sat Dec 31 23:00:00 EST 1983 · J. Toxicol. Environ. Health; (United States) · OSTI ID:5971416

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
AFLATOXIN
ANIMALS
ANTIGENS
AQUATIC ORGANISMS
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CARCINOGENESIS
CARCINOMAS
CHLORINATED AROMATIC HYDROCARBONS
CYTOCHROMES
DIET
DIGESTIVE SYSTEM
DISEASE INCIDENCE
DISEASES
DNA ADDUCTS
FISHES
FLAVENOIDS
FLAVONES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
INDOLES
LIVER
MATERIALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATHOGENESIS
PHARMACOLOGY
PIGMENTS
PROMOTERS
PROTEINS
PYRROLES
RECOVERY
REPAIR
TOXIC MATERIALS
TOXINS
TROUT
TUMOR PROMOTERS
VERTEBRATES