Induction of hepatic tumors with 7,12-dimethylbenz(a)anthracene in two species of viviparous fishes (genus Poeciliopsis)

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90089-5· OSTI ID:5653797

Schultz, M E; Schultz, R J

Liver neoplasms were induced in two species of viviparous fishes, Poeciliopsis lucida and P. monacha, by repeated short-term exposures to an aqueous suspension of 5 ppm 7,12-dimethylbenz(a)anthracene (DMBA). Predominantly hepatocellular neoplasms developed in 47 out of 106 fish surviving the period allowed for tumor development, 6-9 months after initial exposure to DMBA. The use of short-term exposure periods of 6 hr in young fish and up to 20 hr in adults reduced stress and mortalities caused by the toxicity of DMBA at 5 ppm. A lower concentration of DMBA, 0.25 ppm, failed to induce tumors in any of the surviving 230 of 295 young fish administered repeated 20-hr exposures. This study shows for the first time that DMBA is carcinogenic to fish.

• Research Organization: Univ. of Connecticut, Storrs
• OSTI ID: 5653797
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 27:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DIMETHYLBENZANTHRACENE
DISEASES
FISHES
GLANDS
LIVER
NEOPLASMS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANS
VERTEBRATES