Dibenz(a,c)anthracene: a potent inhibitor of skin-tumor initiation by 7,12-dimethylbenz(a)anthracene

Journal Article · Tue Feb 28 23:00:00 EST 1978 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:6040807

Slaga, T J ^[1]; Viaje, A; Buty, S G; Bracken, W M

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1. Oak Ridge National Lab., TN

The mechanism by which the weak tumor initiator dibenz(a,c)anthracene (DB(a,c)A) inhibits the skin-tumor-initiating activity of 7,12-dimethylbenz(a)anthracene (DMBA) was investigated. DB(a,c)A was found to be a potent inhibitor of DMBA initiation when given either 5 min, or 1, 12, or 36 hours before DMBA. Pretreatment of mice with unlabeled DB(a,c)A at either 1, 12, or 36 hours before killing increased the in vitro epidermally mediated covalent binding of (/sup 3/H)DMBA to DNA more than pretreatment with unlabeled DMBA at comparable times. Only when the tumor experiments were mimicked did a decrease in DMBA covalent binding to DNA in vitro occur. The results suggest that some competition at the level of polycyclic hydrocarbon metabolism or at the genome level may exist between metabolites of the weak carcinogen and those of the strong carcinogen.

• OSTI ID: 6040807
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 19:3; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZANTHRACENE
BIOCHEMICAL REACTION KINETICS
BODY
CHEMICAL BONDS
CONDENSED AROMATICS
DISEASES
DNA
HYDROCARBONS
IN VITRO
INHIBITION
KINETICS
MAMMALS
MICE
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
REACTION KINETICS
RODENTS
SKIN
TIME DEPENDENCE
VERTEBRATES