Potent tumor-initiating activity of the 3,4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene in mouse skin

Journal Article · Fri Jun 01 00:00:00 EDT 1979 · Cancer Res.; (United States)

OSTI ID:7097025

Slaga, T J ^[1]; Gleason, G L; DiGiovanni, J; Sukumaran, K B; Harvey, R G

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1. Oak Ridge National Lab., TN

The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and that the bay region diol-epoxide may be the ultimate carcinogenic form of DMBA.

• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7097025
• Journal Information: Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DIMETHYLBENZANTHRACENE
DISEASES
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SKIN
VERTEBRATES