Direct enantiomeric resolution of some 7,12-dimethylbenz(a)anthracene derivatives by high-performance liquid chromatography with ionically and covalently bonded chiral stationary phases

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00278a009· OSTI ID:5789203

Yang, S K; Weems, H B

The direct resolution of the enantiomers of trans-3,4-dihydrodiol, trans-5,6-dihydrodiol, cis-5,6-dihydrodiol, trans-8,9-dihydrodiol, and 8,9,10,11-tetrahydro-trans-8,9-diol of 7,12-dimethylbenz(a)anthracene was evaluated by high-performance liquid chromatography using commercially available columns packed with (R)-N-(3,5-dinitrobenzoyl)phenylglycine and (S)-N-(3,5-dinitrobenzoyl)leucine either ionically or covalently bonded to ..gamma..-aminopropylsilanized silica. The enantiomers of all diol derivatives were resolved by one or more, but not all, of the chiral stationary phases tested. Resolution of enantiomers was confirmed by ultraviolet-visible absorption, mass, and circular dichroism spectral analyses.

• Research Organization: Uniformed Services Univ. of the Health Sciences, Bethesda, MD
• OSTI ID: 5789203
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 56:14; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102* -- Chemical & Spectral Procedures
400301 -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
ALCOHOLS
AROMATICS
CARCINOGENS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
CONDENSED AROMATICS
DATA
DIMETHYLBENZANTHRACENE
ENANTIOMORPHS
EXPERIMENTAL DATA
GLYCOLS
HYDROCARBONS
HYDROXY COMPOUNDS
INFORMATION
LIQUID COLUMN CHROMATOGRAPHY
MUTAGENS
NUMERICAL DATA
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
QUALITATIVE CHEMICAL ANALYSIS
SEPARATION PROCESSES
STRUCTURAL CHEMICAL ANALYSIS