Antiradiation compounds. XVI. N-heterocyclic aminoethyl disulfides and aminoethanethiosulfuric acids

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600650830· OSTI ID:7254591

Foye, W O; Lowe, Y H; Lanzillo, J J

A series of N-heterocyclic and N-heterocyclic alkyl derivatives of bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid was synthesized as potential antiradiation and anticancer agents. The compounds were prepared by the reactions of the heterocyclic halides with bis(2-aminoethyl) disulfide and aminoethanethiosulfuric acid. A dithio acid derivative, 3,3-dimercapto-2-cyanoacryloylpyrrolidide, was also prepared. Several compounds, including the dithio acid derivative, provided good radiation protection to mice. None of the compounds screened showed appreciable anticancer activities in two leukemia systems.

• Research Organization: Massachusetts Coll. of Pharmacy, Boston
• OSTI ID: 7254591
• Journal Information: J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 65:8; ISSN JPMSA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMICAL PREPARATION
DISULFIDES
DRUGS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
SYNTHESIS
THIOSULFATES