Antiradiation compounds XVII: binding ability of radiation-protective N-heterocyclic aminoethyl disulfides and thiosulfides to DNA

Journal Article · Tue Jan 01 04:00:00 EST 1980 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600690123· OSTI ID:6775701

Foye, W O; Karkaria, M M; Parsons, W H

Binding parameters for a series of N-heterocyclic aminoethyl disulfides and thiosulfates to DNA were determined at different ionic strengths and pH values. None of the thiosulfates showed any binding ability, but the disulfides revealed DNA binding abilities that were suppressed both by increased ionic strength and hydrogen-ion concentration. No correlation between DNA binding ability and radiation protective activity in mice was evident.

• Research Organization: Massachusetts Coll. of Pharmacy, Boston
• OSTI ID: 6775701
• Journal Information: J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 69:1; ISSN JPMSA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
CHEMICAL BONDS
DISULFIDES
DNA
EVALUATION
FLUCTUATIONS
IONIC COMPOSITION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PH VALUE
RADIATION PROTECTION
THIOSULFATES
VARIATIONS