Metal-binding abilities of radioprotective aminoalkyl disulfides and thiosulfates

Journal Article · Thu Feb 01 04:00:00 EST 1979 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600680221· OSTI ID:5654359

Foye, W O; Hu, J M

Metal-binding stability constant for several heterocyclic aminoalkyl disulfides and thiosulfates with Ni (II) and Al (III) were determined. The data obtained indicated that both classes of compounds were acting as bidentate chelating agents and that the heterocyclic rings apparently prevented tridentate behavior of the disulfides because of steric hindrance. The magnitude of the constants indicated that metal complexes of these compounds could exist in a cellular environment, but no correlation with radiation-protective activity was apparent.

• Research Organization: Massachusetts Coll. of Pharmacy, Boston
• OSTI ID: 5654359
• Journal Information: J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 68:2; ISSN JPMSA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
CHELATING AGENTS
CHEMICAL BONDS
CHEMICAL PROPERTIES
COMPLEXES
DISULFIDES
DRUGS
ELEMENTS
METALS
NICKEL
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
STABILITY
THIOSULFATES
TRANSITION ELEMENTS