Antiradiation compounds XIX: metal-binding abilities of thioureas

Journal Article · Sat Sep 01 04:00:00 EDT 1984 · J. Pharm. Sci.; (United States)

DOI:https://doi.org/10.1002/jps.2600730924· OSTI ID:5948057

Foye, W O; Chao, C C

Metal-binding stability constants for a series of N- and N,N'-substituted thioureas with Cu(II), Ni(II), Al(III), and Fe(III) ions were determined by potentiometric titration. The sequence of constants for thiourea, N-methylthiourea, and N,N'-dimethylthiourea indicated steric effects of the methyl groups and that both nitrogen and sulfur were involved in the complexation. The magnitude of the constants was somewhat lower than those of the simple peptides. The mechanism of protection against ionizing radiation by thioureas is probably due to hydrogen-atom transfer rather than binding of metal ions that catalyze cellular oxidations.

• Research Organization: Massachusetts Coll. of Pharmacy and Allied Health Sciences, Boston
• OSTI ID: 5948057
• Journal Information: J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 73:9; ISSN JPMSA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
ALUMINIUM COMPOUNDS
BINDING ENERGY
CARBONIC ACID DERIVATIVES
CATIONS
CHARGED PARTICLES
CHEMISTRY
COPPER COMPOUNDS
DRUGS
ELEMENTS
ENERGY
IONS
IRON COMPOUNDS
NICKEL COMPOUNDS
NITROGEN
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POTENTIOMETRY
RADIOPROTECTIVE SUBSTANCES
STABILITY
SULFUR
THIOUREAS
TITRATION
TRANSITION ELEMENT COMPOUNDS