Antiradiation Compounds XV: Condensations of Carbon Disulfide with Amino, Chloro, Cyanomethyl, and Sulfonamido Heterocycles

Journal Article · Fri Aug 01 04:00:00 EDT 1975 · J. Pharm. Sci., v. 64, no. 8, pp. 1371-1374

DOI:https://doi.org/10.1002/jps.2600640823· OSTI ID:4044341

Foye, W O; Kauffman, J M; Lanzillo, J J; LaSala, E F

Condensations of carbon disulfide were carried out with amino, chloro, and diamino heterocycles to give condensed ring thiazoline-2-thiones and imidazoline-2-thiones, with cyanomethyl heterocycles to give dithio acid derivatives, and with heterocyclic sulfonamides to give sulfonyldithiocarbamates. Of several examples tested, pyrido[3,2-d]thiazoline-2-thione, disodium 2-(5-chloro-2-thienyl)-3,3-dimercaptoacrylonitrile, triethylammonium 4-sulfamoylphenyldithiocarbamate, ammonium β-phenethyldithiocarbamate, and methyl N-(thiophene-2-sulfonyl)dithiocarbamate, only the last-named compound showed any radiation protection for mice. Several compounds gave negative tests for antimalarial activity.

• Research Organization: Massachusetts Coll. of Pharmacy, Boston
• NSA Number: NSA-33-029709
• OSTI ID: 4044341
• Journal Information: J. Pharm. Sci., v. 64, no. 8, pp. 1371-1374, Journal Name: J. Pharm. Sci., v. 64, no. 8, pp. 1371-1374; ISSN JPMSA
• Country of Publication: United States
• Language: English

Related Subjects

*RADIOPROTECTIVE SUBSTANCES-- CHEMICAL PREPARATION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
CARBON SULFIDES
HETEROCYCLIC COMPOUNDS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
RADIOSENSITIVITY EFFECTS