Pyridinium- and quinolinium-2-dithioacetic acid zwitterions: antiradiation and anticancer activities
Journal Article
·
· J. Pharm. Sci.; (United States)
Pyridinium-, quinolinium-, and one pyrimidinium-2-dithioacetic acid zwitterions were prepared by condensation of the N-methyl heterocyclic anhydro bases with carbon disulfide. Reaction of the 2-methylpyridine methiodide anhydro base with carbon disulfide resulted in replacement of the 2-methyl group to give the 1-methylpyridinium-2-dithioacetic acid zwitterion showed appreciable anticancer activity against P-388 lymphocytic leukemia in mice, but the other zwitterions tested showed no activity. No antiiradiation activity was found for 1-methyl-pyridinium-2-dithioacetic acid zwitterion.
- Research Organization:
- Massachusetts Coll. of Pharmacy, Boston
- OSTI ID:
- 5732755
- Journal Information:
- J. Pharm. Sci.; (United States), Journal Name: J. Pharm. Sci.; (United States) Vol. 67:7; ISSN JPMSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL PREPARATION
DRUGS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
PYRIMIDINES
QUINOLINES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
SYNTHESIS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL PREPARATION
DRUGS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
PYRIMIDINES
QUINOLINES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY
RESPONSE MODIFYING FACTORS
RODENTS
SYNTHESIS
VERTEBRATES