Bioavailability of PCDDs and PCDFs of fly ash after semi-chronic oral ingestion by guinea pig and Syrian golden hamster

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(86)90546-1· OSTI ID:7232519

van den Bery, M; de Vroom, E; Olie, K; Hutzinger, O

Groups of guinea pigs and syrian golden hamster were fed 2.5% HCl pre-treated fly ash from the electrostatic precipitator of a municipal incinerator during one, two, and three months, respectively, in the diet. The livers were analyzed for tetra-, penta-, and hexa-chlorinated dibenzo(p)dioxines (PCDDs) and dibenzofurans (PCDFs). In the livers of the hamsters 2,3,7,8-substituted PCDDs and PCDFs were the major isomers retained. In the livers of the guinea pigs 2,3,7,8 substituted PCDDs and PCDF congeners were retained, but also a number of otherwise substituted PCDFs. The PCDF congener which had the highest retention in the livers of guinea pigs was 1,2,3,7,8-PnCDF, 11.3% after 95 days. In the livers of the hamsters highest retention was found for 2,3,4,7,8-PnCDF, 8.4% after 95 days. For most 2,3,7,8-substituted PCDDs and PCDFs the retention in the livers of the guinea pigs and hamsters was not significantly different during the whole period, which could indicate a bioconcentration approaching a linear relationship to the administered dose. Constant relative concentrations in the livers were found for the 2,3,7,8-substituted penta- and hexa-chlorinated PCDDs and PCDF in both species during the three time periods.

• Research Organization: Univ. of Amsterdam, Netherlands
• OSTI ID: 7232519
• Journal Information: Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 15:4; ISSN CMSHA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BENZOFURANS
BIOLOGICAL AVAILABILITY
BODY
CHLORINATED AROMATIC HYDROCARBONS
DATA
DIGESTIVE SYSTEM
EXPERIMENTAL DATA
FLY ASH
FUNCTIONS
FURANS
GLANDS
GUINEA PIGS
HALOGENATED AROMATIC HYDROCARBONS
HAMSTERS
HETEROCYCLIC COMPOUNDS
INCINERATORS
INFORMATION
INGESTION
INTAKE
LIVER
MAMMALS
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RESIDUES
RETENTION FUNCTIONS
RODENTS
VERTEBRATES
WASTES