Bio-availability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by the rat

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(86)90545-X· OSTI ID:7145024

van den Bern, M; van Greevenbroek, M; Olie, K; Hutzinger, O

Groups of rats were fed a diet containing 2.5% HCl pretreated fly ash from the electrostatic precipator of a municipal incinerator during 34, 59, and 99 days. Livers were analyzed for 2,3,4,7,8-pentachlorodibenzofuran and higher chlorinated dibenzo(p)dioxine (PCDDs) and dibenzofurans (PCDFs). All isomers retained in the liver had a 2,3,7,8-chlorine substitution pattern. Total group dose varied between 0.2 and 18 ..mu..g for each individual retained compound. Retention in the liver was highest for 2,3,4,7,8-PnCDF, being 14% of the dose for the group killed on day 99. The other isomers detected in the livers had a retention generally below 10%. The 2,3,7,8-substituted hexa- and hepta- chlorinated PCDDs and PCDFs were retained in the liver in constant relative concentrations throughout the experiment, which closely approached a linear relationship to the administered dose.

• Research Organization: Univ. of Amsterdam, Netherlands
• OSTI ID: 7145024
• Journal Information: Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 15:4; ISSN CMSHA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BENZOFURANS
BIOLOGICAL AVAILABILITY
BODY
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
FLUE GAS
FLY ASH
FURANS
GASEOUS WASTES
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
INCINERATORS
INGESTION
INTAKE
LIVER
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RATS
RESIDUES
RODENTS
VERTEBRATES
WASTES