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Presence of PCDDs and PCDFs in human breast milk from the Netherlands

Journal Article · · Chemosphere; (United States)
; ; ;

Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern. The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2-2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2-5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3-19.1) and OCDD (1.7-37.8 ppt) with concentrations on total milk basis. Minor components were 1,2,3,7,8-PhCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (less than or equal to 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for cogeners having an equal number of chlorine atoms or those with a difference of one chlorine atom. Using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months.

Research Organization:
Univ. of Amsterdam, Netherlands
OSTI ID:
5274971
Journal Information:
Chemosphere; (United States), Journal Name: Chemosphere; (United States) Vol. 15:6; ISSN CMSHA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
AROMATICS
BENZOFURANS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHILDREN
CHLORINATED AROMATIC HYDROCARBONS
DIGESTIVE SYSTEM
EUROPE
FEMALES
FOOD
FURANS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
INFANTS
LACTATION
LIVER
MAMMALS
MAN
MATERIALS
MILK
NETHERLANDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
UPTAKE
VERTEBRATES
WESTERN EUROPE
WOMEN