Binders of intravenously administered 65-zinc in rat liver cytoplasm

Technical Report · Wed Dec 31 23:00:00 EST 1975

OSTI ID:7219744

Stortenbeek, A J; Vandenhamer, C J.A.

The fate of an intravenously injected trace dose of Zn-65(2+) in the rat was studied over a period of 10 days after injection. Tissue distributions were determined and a special study was made of Zn-65 binders in liver cytoplasm with apparent molecular weights of about 113,000, 66,400, 47,400, 29,000, 23,000, and 11,400. A time study showed that 4 hr after the injection, the most prominent cytoplasmatic Zn-65 binders are the 133,000, 66,400, and 23,000 molecular weight fractions. A tentative identification of the main Zn binders in the six Zn-65 fractions is given, using the collected data regarding their apparent molecular weight, time dependent prominence, and content of stable Zn.

• Research Organization: Interuniversitair Reactor Instituut, Delft (Netherlands)
• OSTI ID: 7219744
• Report Number(s): N-77-16683; IRI-33-76-02
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CELL CONSTITUENTS
CYTOPLASM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
METABOLISM
MOLECULAR WEIGHT
NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
TISSUE DISTRIBUTION
TRACE AMOUNTS
VERTEBRATES
ZINC 65
ZINC ISOTOPES