Binders of intravenously administered 65-zinc in rat liver cytoplasm
The fate of an i.v. injected trace dose of /sup 65/Zn2+ in the rat, was studied over a period of 10 days after injection. Tissue distributions were determined and a special study was made of /sup 65/Zn binders in liver cytoplasm. A total of 6 /sup 65/Zn-binding fractions were observed in liver cytoplasm with apparent molecular weights of about 113,000, 66,400, 47,400, 29,000, 23,000 and 11,400. A time study showed that 4 hours after the injection the most prominent cytoplasmatic /sup 65/Zn binders are the 113,000, 66,400 and 23,000 molecular weight fractions. A tentative identification of the main Zn binders in the six /sup 65/Zn fractions is given, using the collected data regarding their apparent molecular weight, time dependent prominence and content of stable Zn.
- Research Organization:
- Interuniversitair Reactor Instituut, Delft, The Netherlands
- OSTI ID:
- 6526977
- Journal Information:
- Bioinorg. Chem.; (United States), Journal Name: Bioinorg. Chem.; (United States) Vol. 4; ISSN BICHB
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BODY
CATIONS
CELL CONSTITUENTS
CHARGED PARTICLES
CHEMISTRY
CYTOPLASM
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIVER
MAMMALS
MOLECULAR WEIGHT
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
TIME DEPENDENCE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
ZINC 65
ZINC COMPOUNDS
ZINC ISOTOPES