Additive sensitization of bacterial spores by oxygen and p-nitroacetophenone
Journal Article
·
· Radiat. Res.; (United States)
Ib the bacterial spore, the sensitizing effects of both oxygen and p-nitroacetophenone (PNAP) can be separated into components. Each sensitizer has a component of damage which involves reactions of hydroxyl radicals (.OH), although the origins of these components may be different. Tests which use different concentrations of PNAP and O/sub 2/ simultaneously have been run to seek interactions or additives in their effects on lethal radiation sensitivity. The results show that the effects of the PNAP ''non-.OH'' component are additive to those of both O/sub 2/ ''non-.OH'' components; however, the patterns of this additivity suggest that the chemical processes through which PNAP acts are similar to those of the high-O/sub 2/ component (that is, the component which occurs at (O/sub 2/) > 5 x 10/sup -5/ M) but are different from those of the low-O/sub 2/ component. There is also indirect evidence that the sensitizing reactions of the high-O/sub 2/ component may replace those reactions of hydroxyl radicals which occur at lower (O/sub 2/). If O/sub 2/ does replace .OH in some damaging chemical reactions, the unexpected disappearance of the .OH component as the (O/sub 2/) is raised would be understandable.
- Research Organization:
- Univ. of Texas, Austin
- OSTI ID:
- 7208164
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Journal Article
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Mon Oct 31 23:00:00 EST 1977
· Radiat. Res.; (United States)
·
OSTI ID:5144053
Anoxic radiosensitization of two Bacillus species by p-nitroacetophenone
Journal Article
·
Wed Oct 31 23:00:00 EST 1973
· Int. J. Radiat. Biol., v. 24, no. 5, pp. 505-515
·
OSTI ID:4357912
Application of rapid lysis techniques in radiobioloy. III. The effect of radiosensitizers on the production of DNA damage and the time course of its repair. [Escherichia coli, para-nitroacetophenone, norpseudopelletierine-N-oxyl, gamma radiation]
Journal Article
·
Sat Jul 01 00:00:00 EDT 1978
· Radiat. Res.; (United States)
·
OSTI ID:6952205
Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AQUEOUS SOLUTIONS
BACILLUS
BACILLUS MEGATERIUM
BACTERIA
BACTERIAL SPORES
BIOCHEMICAL REACTION KINETICS
CRYOGENIC FLUIDS
DISPERSIONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HYDROXYL RADICALS
IONIZING RADIATIONS
IRRADIATION
KETONES
KINETICS
MICROORGANISMS
MIXTURES
NITRO COMPOUNDS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
RADIATIONS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
SOLUTIONS
SPORES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AQUEOUS SOLUTIONS
BACILLUS
BACILLUS MEGATERIUM
BACTERIA
BACTERIAL SPORES
BIOCHEMICAL REACTION KINETICS
CRYOGENIC FLUIDS
DISPERSIONS
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HYDROXYL RADICALS
IONIZING RADIATIONS
IRRADIATION
KETONES
KINETICS
MICROORGANISMS
MIXTURES
NITRO COMPOUNDS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
RADIATIONS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
SOLUTIONS
SPORES
X RADIATION