Sensitization of bacterial spores by p-nitroacetophenone (PNAP) and 0. 8% O/sub 2/. Choice of suspending fluid

Journal Article · Mon Oct 31 23:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574698· OSTI ID:5144053

Ewing, D

In the bacterial spore system, both oxygen and p-nitroacetophenone (PNAP) function as radiation sensitizers. Previous work had shown that PNAP has a protective effect in 0.8%O/sub 2/. These results, obtained in phosphate buffer (pH 7.0), have now been compared with results from water-suspension experiments. In water, mixtures of PNAP and oxygen show the same response as 0.8%O/sub 2/ alone; i.e., PNAP does not protect. Although the mechanisms are not understood, the previously observed protection by PNAP in 0.8%O/sub 2/ must be designated as buffer dependent. Therefore, spore studies to examine chemical sensitizing processes of PNAP and O/sub 2/ should be in water, not phosphate buffer.

• Research Organization: Univ. of Texas, Austin
• OSTI ID: 5144053
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 72:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETOPHENONE
BACTERIAL SPORES
BUFFERS
CRYOGENIC FLUIDS
DRUGS
ELEMENTS
FLUIDS
HYDROGEN COMPOUNDS
KETONES
NITRO COMPOUNDS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
OXYGEN COMPOUNDS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
SPORES
WATER