Localization of the Chinese hamster CAD gene reveals homology between human chromosome 2p and Chinese hamster 7q
Journal Article
·
· Genomics; (United States)
- Universita degli Studi di Pavia (Italy)
- Istituto di Mutagenesie Differenziamento, Pisa (Italy)
The trifunctional enzyme CAD catalyzes the first three steps of pyrimidine biosynthesis. By using fluorescence in situ hybridization the authors have localized the Chinese hamster CAD gene on chromosome 7q11-q13 of diploid fibroblasts. Other genes previously assigned to chromosome 7 include acid phosphatase-1, the M2 subunit of ribonucleotide reductase and ornithine decarboxylase. These genes are also syntenic with CAD on human chromosome 2p. They have then mapped CAD on the pericentromeric region of two different rearranged chromosomes (Z8p and R2q) in a cell line derived from Chinese hamster ovary. The presence of CAD on Z8 and R2 indicates that they derive from rearrangements involving chromosome 7. 14 refs., 2 figs.
- OSTI ID:
- 7200033
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 16:3; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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