SPECT assay of radiolabeled monoclonal antibodies

Technical Report · Sat Feb 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/7197646· OSTI ID:7197646

Jaszczak, R J

The long-term goal of this research project is to develop methods to improve the utility of single photon emission computed tomography (SPECI) to quantify the biodistribution of monoclonal antibodies (MoAbs) labeled with clinically relevant radionuclides ({sup 123}I, {sup 131}I, and {sup 111}In) and with another radionuclide,{sup 211}At, recently used in therapy. We describe here our progress in developing quantitative SPECT methodology for {sup 111}In and {sup 123}I. We have focused our recent research thrusts on the following aspects of SPECT: (1) The development of improved SPECT hardware, such as improved acquisition geometries. (2) The development of better reconstruction methods that provide accurate compensation for the physical factors that affect SPECT quantification. (3) The application of carefully designed simulations and experiments to validate our hardware and software approaches.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60894
• OSTI ID: 7197646
• Report Number(s): DOE/ER/60894-4; ON: DE92019915
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ALGORITHMS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COLLIMATORS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MATHEMATICAL LOGIC
MINUTES LIVING RADIOISOTOPES
MOCKUP
MONOCLONAL ANTIBODIES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN 15
OXYGEN ISOTOPES
PATIENTS
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
PROGRESS REPORT
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
THREE-DIMENSIONAL CALCULATIONS
TOMOGRAPHY