SPECT assay of radiolabeled monoclonal antibodies. Comprehensive progress report, September 1989--February 1992

Technical Report · Sat Feb 01 04:00:00 EST 1992

DOI:https://doi.org/10.2172/10170846· OSTI ID:10170846

Jaszczak, R J

The long-term goal of this research project is to develop methods to improve the utility of single photon emission computed tomography (SPECI) to quantify the biodistribution of monoclonal antibodies (MoAbs) labeled with clinically relevant radionuclides ({sup 123}I, {sup 131}I, and {sup 111}In) and with another radionuclide,{sup 211}At, recently used in therapy. We describe here our progress in developing quantitative SPECT methodology for {sup 111}In and {sup 123}I. We have focused our recent research thrusts on the following aspects of SPECT: (1) The development of improved SPECT hardware, such as improved acquisition geometries. (2) The development of better reconstruction methods that provide accurate compensation for the physical factors that affect SPECT quantification. (3) The application of carefully designed simulations and experiments to validate our hardware and software approaches.

• Research Organization: Duke Univ. Medical Center, Durham, NC (United States). Dept. of Radiology
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG05-89ER60894
• OSTI ID: 10170846
• Report Number(s): DOE/ER/60894--4; ON: DE92019915
• Country of Publication: United States
• Language: English

Related Subjects

550601
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ALGORITHMS
BRAIN
COLLIMATORS
DESIGN
FLUORINE 18
IMAGE PROCESSING
IODINE 123
IODINE 131
MONOCLONAL ANTIBODIES
OXYGEN 15
PATIENTS
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
PROGRESS REPORT
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THREE-DIMENSIONAL CALCULATIONS
UNSEALED RADIONUCLIDES IN DIAGNOSTICS