Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene

Journal Article · Fri Apr 01 04:00:00 EST 1988 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.8.4.1857· OSTI ID:7192094

Tanaka, K; Gorelik, E; Watanabe, M; Hozumi, N; Jay, G

Transfection of a functional major histocompatibility complex class I gene into certain tumor cells, induced by oncogenic viruses or chemical carcinogens, can effectively abrogate their tumorigenic activity. Since experimentally induced tumors possess strong tumor-specific transplantation antigens, expression of cell surface class I antigens may present the tumor cells to appropriate immune effector cells. Most spontaneously arising tumors do not possess tumor-specific transplantation antigens, and their tumorigenicity may not be affected by the expression of a transfected class I gene. The authors demonstrate that the poorly immunogenic B16-BL6 melanoma can be rendered nontumorigenic in syngeneic mice by the expression of the class I H-2K antigen but not the class II I-A antigen. Furthermore, the poorly tumorigenic, class I-expression B16-BL6-transfected cells can effectively immunize syngeneic C57BL/6 mice against the highly tumorigenic, class I-deficient B16-BL6 parental cells. The authors' success in experimentally manipulating the tumorigenicity of a spontaneously derived neoplasm offers hope for a potential modality for the effective treatment of human cancer.

• Research Organization: Lab. of Molecular Virology, National Cancer Institute, Bethesda, MD (US)
• OSTI ID: 7192094
• Journal Information: Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 8:4; ISSN MCEBD
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
CARCINOGENESIS
CARCINOGENS
CARCINOMAS
DISEASES
EXPERIMENTAL NEOPLASMS
GENES
GENETIC ENGINEERING
GRAFTS
IMMUNOLOGY
MALES
MAMMALS
MAN
MELANOMAS
MEN
MICE
MICROORGANISMS
MOLECULAR BIOLOGY
NEOPLASMS
ONCOGENIC VIRUSES
PARASITES
PATHOGENESIS
PHENOTYPE
PRIMATES
RODENTS
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
VIRUSES