Studies on the blood-aqueous barrier after argon laser photocoagulation of the iris
Journal Article
·
· Ophthalmology (Rochester, Minn.); (United States)
Breakdown and re-establishment of the blood-aqueous barrier (BAB) was studied following laser irradiation to the rabbit iris by quantitating leakage of protein, fluorescein, and fluorescein-labeled dextran (FLD-70, MW 70,000) into the aqueous humor. Breakdown of the BAB was more prolonged in pigmented than albino animals, possibly due to the increased laser energy absorbed by the pigmented iris. Fluorophotometry appeared to be a more sensitive method for evaluating BAB breakdown than aqueous protein measurements, and small molecule leakage (fluorescein) appeared to be more sensitive than macromolecule leakage (FLD-70). The noninvasive method of evaluating the BAB proved equally as effective as measuring aqueous protein content in assessing the sensitivity of laser-induced trauma to the ameliorating effect of the nonsteroidal anti-inflammatory agent indomethacin.
- Research Organization:
- Univ. of Illinois at the Medical Center, Chicago
- OSTI ID:
- 7188356
- Journal Information:
- Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 90:2; ISSN OPHTD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD SUBSTITUTES
BODY
BODY AREAS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
DEXTRAN
DIAGNOSIS
DRUGS
DYES
ELECTROMAGNETIC RADIATION
EYES
FACE
FLUORESCEIN
GAS LASERS
HEAD
HEMATOLOGIC AGENTS
HYDROXY ACIDS
HYDROXY COMPOUNDS
INJURIES
LASER RADIATION
LASERS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POLYSACCHARIDES
PROTEINS
RABBITS
RADIATIONS
SACCHARIDES
SENSE ORGANS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD SUBSTITUTES
BODY
BODY AREAS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
DEXTRAN
DIAGNOSIS
DRUGS
DYES
ELECTROMAGNETIC RADIATION
EYES
FACE
FLUORESCEIN
GAS LASERS
HEAD
HEMATOLOGIC AGENTS
HYDROXY ACIDS
HYDROXY COMPOUNDS
INJURIES
LASER RADIATION
LASERS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POLYSACCHARIDES
PROTEINS
RABBITS
RADIATIONS
SACCHARIDES
SENSE ORGANS
VERTEBRATES