Apraclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris
Journal Article
·
· Investigative Ophthalmology and Visual Science; (USA)
OSTI ID:6866571
- Gifu Univ. School of Medicine (Japan)
Apraclonidine (p-aminoclonidine) ophthalmic solution effectively reduces the rise in intraocular pressure (IOP) following anterior segment laser surgery. We tested the effect of topical 0.5% apraclonidine on intraocular pressure and on protein and prostaglandin (PG) E2 concentrations in aqueous humor following Q-switched Nd:YAG laser irradiation to the iris of albino rabbits, at an energy level of 2 to 200 mJ. IOP was measured prior to and for 24 hr after irradiation. Aqueous humor was withdrawn before and 1 hr after laser irradiation for determining protein (Lowry method) and PGE2 (radioimmunoassay). Four to seven rabbits were used for each experiment. The increase in IOP and protein concentration following laser irradiation was demonstrated to be dependent on the amount of laser energy. Apraclonidine completely abolished the IOP rise, and significantly reduced the elevation of protein content. Apraclonidine failed to affect the increase in PGE2.
- OSTI ID:
- 6866571
- Journal Information:
- Investigative Ophthalmology and Visual Science; (USA), Journal Name: Investigative Ophthalmology and Visual Science; (USA) Vol. 31:4; ISSN 0146-0404; ISSN IOVSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LASER RADIATION
LASERS
MAMMALS
NEODYMIUM LASERS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
PROTEINS
RABBITS
RADIATIONS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SENSE ORGANS
SENSITIVITY
SOLID STATE LASERS
TRACER TECHNIQUES
VERTEBRATES
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIAGNOSTIC TECHNIQUES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LASER RADIATION
LASERS
MAMMALS
NEODYMIUM LASERS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
PROTEINS
RABBITS
RADIATIONS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SENSE ORGANS
SENSITIVITY
SOLID STATE LASERS
TRACER TECHNIQUES
VERTEBRATES