Prostaglandin E2 and protein levels in rabbit aqueous humor following ND:YAG laser iridotomy

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Metabolic, Pediatric and Systemic Ophthalmology; (USA)

OSTI ID:5345302

Rosner, M; Gelerstein, S; Weissman, C; Naveh, N ^[1]

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1. Tel-Aviv Univ. Sackler School of Medicine, Tel-Hashomer (Israel)

Prostaglandin E2 (PGE2) and protein levels were measured in the aqueous humor of rabbits' eyes subjected to iridotomy with the neodymium:YAG laser. Following irradiation, PGE2 levels were elevated to the highest elevation of 20.0 {plus minus} 7.7 ng/ml (mean {plus minus} SD) at 30 minutes as compared to control levels of 0.625 {plus minus} 0.075 ng/ml. PGE2 concentrations progressively decreased, however, after 8 hours they remained high and did not resume control levels. Protein levels in the aqueous humor of ND:YAG irradiated eyes reached peak levels at 30 minutes to 7.8 {plus minus} 2.2 mg/ml compared to control level of 1.3 {plus minus} 0.4 mg/ml. A progressive decrease in protein levels was observed after peak time, but they were still above control levels, at 8 hours. Our study demonstrated that ND:YAG irradiation of the iris involves an immediate increase in PGE2 aqueous levels associated with a blood aqueous barrier disruption and augmented aqueous protein levels.

• OSTI ID: 5345302
• Journal Information: Metabolic, Pediatric and Systemic Ophthalmology; (USA), Journal Name: Metabolic, Pediatric and Systemic Ophthalmology; (USA) Vol. 11:1-2; ISSN MPSOD; ISSN 0882-889X
• Country of Publication: United States
• Language: English

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