Platelet-activating factor and laser trauma of the iris
Journal Article
·
· Invest. Ophthalmol. Visual Sci.; (United States)
OSTI ID:5713482
Local application of platelet-activating factor (PAF) on the rabbit eye caused a dose-dependent significant increase in intraocular pressure (IOP). After laser irradiation of the iris the IOP showed a hypertensive phase of about 3 hr. Prophylactic treatment with the PAF antagonist BN 52021 but not with indomethacin abolished the hypertensive phase. Elevated levels of protein (10.6 +/- 0.9 g/l) and prostaglandin E2 (PGE2, 1.7 +/- 0.2 ng/ml) were measured in the aqueous humor 2 hr after laser irradiation of the iris. Prophylactic treatment with BN 52021 showed lower levels of protein (6.1 +/- 0.7) and PGE2 (1.1 +/- 0.02); with indomethacin pretreatment the level of protein was 3.4 +/- 0.7 g/l and of PGE2 0.10 +/- 0.02 ng/ml. A role of PAF as a mediator in ocular inflammatory response is suggested.
- Research Organization:
- Eye Hospital, Rotterdam (Netherlands)
- OSTI ID:
- 5713482
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Journal Name: Invest. Ophthalmol. Visual Sci.; (United States) Vol. 30:6; ISSN IOVSD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BODY
BODY AREAS
BODY FLUIDS
COAGULANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
LACTONES
LASER RADIATION
LASERS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
PROTEINS
RABBITS
RADIATIONS
SENSE ORGANS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL STRESS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BODY
BODY AREAS
BODY FLUIDS
COAGULANTS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
ESTERS
EYES
FACE
HEAD
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
LACTONES
LASER RADIATION
LASERS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
PROTEINS
RABBITS
RADIATIONS
SENSE ORGANS
VERTEBRATES