Activation of brown adipose tissue mitochondrial GDP binding sites
Thesis/Dissertation
·
OSTI ID:7188086
The primary function of brown adipose tissue (BAT) is heat production. This ability is attributed to the existence of a unique inner mitochondrial membrane protein termed the uncoupling protein or thermogenin. This protein is permeable to H+ and thus allows respiration (and therefore thermogenesis) to proceed at a rapid rate, independent of ADP phosphorylation. Proton conductance can be inhibited by the binding of purine nucleotides to the uncoupling protein. The binding of (/sup 3/H)-GDP to BAT mitochondria is frequently used as a measure of BAT thermogenic activity. Rats fed a diet that was low but adequate in protein exhibited a decrease in feed efficiency. In addition, BAT thermogenesis was activated as indicated by an elevation in the level of GDP binding to BAT mitochondria. This phenomena occurred in older rats and persisted over time.
- Research Organization:
- Wisconsin Univ., Madison (USA)
- OSTI ID:
- 7188086
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BODY
CELL CONSTITUENTS
CONNECTIVE TISSUE
FUNCTIONS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
MITOCHONDRIA
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANOIDS
PROTEINS
REACTION KINETICS
RECEPTORS
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BODY
CELL CONSTITUENTS
CONNECTIVE TISSUE
FUNCTIONS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
MITOCHONDRIA
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANOIDS
PROTEINS
REACTION KINETICS
RECEPTORS
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS