Effect of marginal zinc deficiency on the lymphatic absorption of /sup 14/C-cholesterol

Conference · Wed Mar 05 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:7186548

Koo, S I; Norvell, J E; Algilani, K; Chow, J

The effect of zinc deficiency on intestinal absorption of cholesterol was investigated in adult male rats fed 3 ppm of dietary zinc (ZD), as compared with pair-fed (PF) and adlibitum (CT) controls fed 30 ppm of zinc for 10 to 12 weeks. The intestinal absorption of cholesterol was measured by collecting the mesenteric lymph at hourly intervals for 8 hrs after infusing a dose of /sup 14/C-cholesterol in a lipid emulsion through an indwelling duodenal catheter. Data on the hourly lymphatic output of /sup 14/C-cholesterol showed that the absorption of /sup 14/C-cholesterol plateaued at 4 hrs post dosing in all groups. A significant decrease in /sup 14/C-cholesterol absorption was observed in ZD rats at 5 hrs and thereafter. The cumulative absorption of /sup 14/C-cholesterol by ZD rats for the 8-hour period was 4.4 +/- 1.0% of the dose, as compared with 11.8 +/- 1.1% by PF and 10.7 +/- 1.4% by CT rats. There were no differences in percent distribution of esterified /sup 14/C-cholesterol among the 3 groups. Also, no significant change in mucosal cholesterol esterase activity was observed due to zinc deficiency. The present data and previous findings taken together suggest that the primary mechanism responsible for the impaired absorption of cholesterol in zinc deficiency may be associated with defective formation of chylomicrons in the intestinal mucosa.

• Research Organization: Oral Roberts Univ. School of Medicine, Tulsa, OK
• OSTI ID: 7186548
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBON 14 COMPOUNDS
CHOLESTEROL
CHYLOMICRONS
ELEMENTS
ENZYMES
ESTERASES
HYDROLASES
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LYMPH
MAMMALS
MATERIALS
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
RATS
RODENTS
STEROIDS
STEROLS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
ZINC