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Title: Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats

Abstract

Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.

Authors:
; ; ;
Publication Date:
Research Org.:
Oral Roberts Univ. School of Medicine, Tulsa, OK
OSTI Identifier:
5674337
Resource Type:
Journal Article
Journal Name:
Am. J. Clin. Nutr.; (United States)
Additional Journal Information:
Journal Volume: 3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; CHOLESTEROL; BLOOD-PLASMA CLEARANCE; ZINC; BIOLOGICAL EFFECTS; NUTRITIONAL DEFICIENCY; CARBON 14 COMPOUNDS; CHYLOMICRONS; LIVER; RATS; ANIMALS; BODY; CLEARANCE; DIGESTIVE SYSTEM; ELEMENTS; GLANDS; HYDROXY COMPOUNDS; LABELLED COMPOUNDS; MAMMALS; METALS; ORGANIC COMPOUNDS; ORGANS; RODENTS; STEROIDS; STEROLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 551001 - Physiological Systems- Tracer Techniques

Citation Formats

Koo, S I, Algilani, K, Norvell, J E, and Henderson, D A. Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats. United States: N. p., 1986. Web.
Koo, S I, Algilani, K, Norvell, J E, & Henderson, D A. Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats. United States.
Koo, S I, Algilani, K, Norvell, J E, and Henderson, D A. Sat . "Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats". United States.
@article{osti_5674337,
title = {Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats},
author = {Koo, S I and Algilani, K and Norvell, J E and Henderson, D A},
abstractNote = {Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.},
doi = {},
journal = {Am. J. Clin. Nutr.; (United States)},
number = ,
volume = 3,
place = {United States},
year = {1986},
month = {3}
}