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Delayed plasma clearance and hepatic uptake of lymph chylomicron 14C-cholesterol in marginally zinc-deficient rats

Journal Article · · Am. J. Clin. Nutr.; (United States)
OSTI ID:5674337
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Previously, chylomicrons from marginally zinc-deficient rats were shown to be abnormally large, with markedly reduced levels of apoproteins C and E. In the present study, effects of such changes on the plasma clearance and hepatic uptake of chylomicron cholesterol were investigated in rats fed 3 ppm of zinc (ZD), as compared with those fed 30 ppm of zinc (CT). The rate of plasma clearance was determined by plasma 14C-radioactivity at different intervals after intravenous injection of lymph chylomicrons labeled in vivo with 14C-cholesterol. The 14C-clearance curves were nonlinear, consisting of an initial rapid phase followed by a slow phase of clearance. The initial 14C-clearance was significantly (p less than 0.05) delayed whether the labeled chylomicrons from ZD donors were injected into ZD or CT recipients. The hepatic 14C-recovery in extracted lipids was also significantly lower in ZD rats. The present data provide first evidence that a marginal level of zinc deficiency produces a significant delay in the plasma clearance and hepatic uptake of chylomicron cholesterol. This may be attributable in part to the molecular alterations of chylomicrons induced by zinc deficiency.
Research Organization:
Oral Roberts Univ. School of Medicine, Tulsa, OK
OSTI ID:
5674337
Journal Information:
Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 3; ISSN AJCNA
Country of Publication:
United States
Language:
English

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Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BLOOD-PLASMA CLEARANCE
BODY
CARBON 14 COMPOUNDS
CHOLESTEROL
CHYLOMICRONS
CLEARANCE
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
LIVER
MAMMALS
METALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
STEROIDS
STEROLS
VERTEBRATES
ZINC