Chronic effects of inhaled benzene and ingested ethanol on erythroid progenitor cells in C57Bl/6J mice

Thesis/Dissertation · Wed Dec 31 23:00:00 EST 1986

OSTI ID:7160777

Baarson, K A

Exposure of male C57Bl mice for 6 hr/day x 5 day/week to 10 ppm over 178 days or 300 ppm benzene over 60 days in combination with 0% or 5% ethanol in the drinking water 4 days/week for the same time periods produced changes in the in vitro colony forming ability of the erythroid progenitor cells BFUE and CFUE, as well as recognizable erythroid precursors, and mature and red cells. Depressions in marrow CFUE with more severe in mice exposed to 300 ppm benzene in combination with ethanol than in mice exposed to benzene alone. For mice exposed to 300 ppm benzene and ethanol, depressions in marrow and splenic BFUE, CFUE, and normoblasts were followed by transient increases in spleen FLUE, marrow, and spleen CFUE, and normoblasts, and the appearance of nucleated red cells in the peripheral blood. In contrast, only marrow normoblasts and spleen CFUE increased following initial depressions in mice treated with 300 ppm benzene alone.

• Research Organization: New York Univ., NY (USA)
• OSTI ID: 7160777
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHRONIC EXPOSURE
ERYTHROCYTES
ETHANOL
HEMATOPOIETIC SYSTEM
HYDROCARBONS
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
ORGANS
RODENTS
SENSITIVITY
SPLEEN
SYNERGISM
TISSUES
TOXICITY
VERTEBRATES