Benzene hematotoxicity and leukemogenesis

Journal Article · Tue Jan 01 04:00:00 EST 1985 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700070509· OSTI ID:6185715

Cronkite, E P; Drew, R T; Inoue, T; Bullis, J E

Eight-to-twelve-week-old male and female C57B1/6 BNL mice were exposed to air or benzene vapor in air at a concentration of 10, 25, 100, 300, or 400 ppm. Benzene at concentrations of 100 ppm or higher for 10 exposures of 6 hours per day 5 days a week produced a reduction in bone marrow cellularity and the number of pluripotent stem cells in the bone marrow. The fraction of stem cells in DNA synthesis was also increased. Exposure to 300 ppm 6 hours a day 5 days a week for 2, 4, 8, and 16 weeks produced a diminution in the stem cell levels in bone marrow which returned to those of controls 2 weeks after benzene exposure for 2 and 4 weeks, 16 weeks after exposure for 8 weeks, and to 92% of controls 25 weeks after 16 weeks of exposure. There was a more rapid return of blood lymphocytes to the control level. Mice exposed to 300 ppm for 6 hours/day, 5 days per week for 16 weeks began dying at 330 days of age, whereas no deaths were observed in sham-exposed mice until 440 days of age. The benzene-exposed mice died in two waves: the first was from 330-390 days of age, with a second wave commencing at 570 days of age. The first wave of mortality was due primarily to thymic lymphomata. The second wave was due to a mixture of nonthymic lymphomata and solid tumors. 19 references, 7 figures, 1 table.

• Research Organization: Brookhaven National Lab., Upton, NY
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6185715
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 7; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CARCINOGENESIS
CONNECTIVE TISSUE CELLS
DATA
DISEASES
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
ECOLOGICAL CONCENTRATION
EXPERIMENTAL DATA
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HYDROCARBONS
INFORMATION
LEUKEMIA
LEUKEMOGENESIS
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NEOPLASMS
NUCLEIC ACID REPLICATION
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SOMATIC CELLS
STEM CELLS
THYMUS
TISSUES
TOXICITY
VERTEBRATES