Toxicity of chronic benzene inhalation: CD-1 mice exposed to 300 ppm

Journal Article · Fri Oct 01 00:00:00 EDT 1982 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01605600· OSTI ID:5743865

Snyder, C A; Goldstein, B D; Sellakumar, A; Bromberg, I; Laskin, S; Albert, R E

Male, six-week old mice were exposed to benzene in an inhalation chamber for 6 hr/day, 5 days/wk. Red cell, white cell and white cell differential counts were performed. Tissues routinely sectioned at autopsy included lung, liver, spleen, bone marrow and kidney, as well as abnormally appearing organs. Hemototoxic responses observed include immediate depression of peripheral lymphocytes and red blood cells, and an increase in circulating granulocytes. Exposed animals dying with bone hypoplasia survived about 75 fewer days than mice dying with bone hyperplasia. The appearance of hemosiderin pigments in the spleens is evidence for benzene-induced hemolysis. (JMT)

• Research Organization: New York Univ. Medical Center
• OSTI ID: 5743865
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 29:4; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY FLUIDS
CARBOXYLIC ACIDS
CONNECTIVE TISSUE CELLS
ERYTHROCYTES
ERYTHROPOIESIS
HEMOLYSIS
HEMOSIDERIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INHALATION
INTAKE
LEUKOCYTES
LYMPHOCYTES
LYSIS
MAMMALS
MATERIALS
METALLOPROTEINS
MICE
MORTALITY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES