Effects of amorphous and crystalline nickel sulfide on induction of induction of interferons-. alpha. /. beta. and -. gamma. and interleukin-2

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Environmental Research; (USA)

DOI:https://doi.org/10.1016/S0013-9351(89)80040-4· OSTI ID:7149844

Jaramillo, A; Sonnenfeld, G ^[1]

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1. Univ. of Louisville, KY (USA)

Pretreatment of rat spleen cells with crystalline or amorphous nickel sulfide (NiS) did not inhibit induction of interferon-{gamma} or interleukin-2 by concanavalin A. In contrast, pretreatment of murine L-929 cells with crystalline NiS inhibited severely IFN-{alpha}/{beta} induction by polyriboinosinic-polyribocytidylic acid, while amorphous NiS did not show any effect. This difference in the effects of both forms of NiS on the spleen and L-929 cells correlated with the cellular internalization of the compound; L-929 cells actively phagocytosed crystalline NiS while the uptake of amorphous NiS by the same type of cells was minimal. The uptake of both crystalline and amorphous NiS by spleen cells was very low.

• OSTI ID: 7149844
• Journal Information: Environmental Research; (USA), Journal Name: Environmental Research; (USA) Vol. 48:2; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMORPHOUS STATE
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
CHALCOGENIDES
COMPARATIVE EVALUATIONS
CRYSTAL STRUCTURE
GROWTH FACTORS
KINETICS
LYMPHOKINES
MAMMALS
MICE
MITOGENS
NICKEL COMPOUNDS
NICKEL SULFIDES
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTOSIS
PROTEINS
RATS
REACTION KINETICS
RODENTS
SPLEEN
STRUCTURE-ACTIVITY RELATIONSHIPS
SULFIDES
SULFUR COMPOUNDS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VERTEBRATES