Kinetics of activation of benzo(a)pyrene for inhibition of interferon induction
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:6956047
The induction of interferon-alpha/beta (IFN-..cap alpha../..beta..) by polyribosinosinic-polyribocytidylic acid was inhibited when murine L-929 cells were pretreated with the carcinogen benzo(a)pyrene (BP). Exposure of L-929 cells for 24 hr to BP was required to inhibit IFN-..cap alpha../..beta.. induction. When the BP was activated to the ultimate carcinogenic form in an in vitro cell-free liver microsomal enzyme system, the exposure time of L-929 cells to BP required for inhibition of IFN induction was decreased to 3 hr. BP dosages required for inhibition of IFN induction were not altered when the BP was preactivated, and the degree of inhibition of interferon induction was related to the concentration of microsomal enzymes added to the cell-free activation system.
- Research Organization:
- Univ. of Louisville, KY
- OSTI ID:
- 6956047
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 38:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
GROWTH FACTORS
HYDROCARBONS
IN VITRO
INTERFERON
KINETICS
L CELLS
LYMPHOKINES
MAMMALS
METABOLIC ACTIVATION
MICE
MITOGENS
ORGANIC COMPOUNDS
PROTEINS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
TIME DEPENDENCE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
GROWTH FACTORS
HYDROCARBONS
IN VITRO
INTERFERON
KINETICS
L CELLS
LYMPHOKINES
MAMMALS
METABOLIC ACTIVATION
MICE
MITOGENS
ORGANIC COMPOUNDS
PROTEINS
REACTION KINETICS
RESPONSE MODIFYING FACTORS
RODENTS
TIME DEPENDENCE
VERTEBRATES