Characteristics of the inhibition-. alpha. /. beta. production after crystalline nickel sulfide exposure

Journal Article · Sat Feb 01 04:00:00 EST 1992 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80021-0· OSTI ID:7235912

Jaramillo, A; Sonnenfeld, G ^[1]

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1. Univ. of Louisville, KY (United States)

Murine L-929 cells were treated with crystalline nickel sulfide (NiS), washed, and then exposed to polyriboinosinic-polyribocytidylic acid (Poly I:C) to induce interferon-{alpha}/{beta} (IFN-{alpha}{beta}). Addition of crystalline NiS at different time points, from 24 hr prior to IFN induction up to 12 hr after IFN induction, resulted in significant inhibition of IFN-{alpha}/{beta} production. In addition, 24-hr pretreatment of L-929 cells with crystalline NiS resulted in significantly decreased production of IFN-{alpha}/{beta} even 120 hr after addition of IFN inducer. IFN-{alpha}/{beta} at a known concentration was titered by means of a viral plaque reduction assay in crystalline NiS-treated L-929 cell cultures. Crystalline NiS did not show a significant inhibitory effect on the antiviral activity of IFN on L-929 cells as compared to controls. The results described here suggest that NiS has a rapid and a long-lasting inhibitory activity on the production of IFN-{alpha}/{beta}.

• OSTI ID: 7235912
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 57:1; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
ELEMENTS
GROWTH FACTORS
INHIBITION
INTERFERON
LYMPHOKINES
MAMMALS
METABOLISM
METALS
MICE
MITOGENS
NICKEL
ORGANIC COMPOUNDS
PROTEINS
RODENTS
SYNTHESIS
TRANSITION ELEMENTS
VERTEBRATES