Ethanol increase PGE and thromboxane production in mouse pregnant uterine tissue

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90451-V· OSTI ID:7136219

Anton, R F; Becker, H C; Randall, C L ^[1]

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1. Veterans Administration Medical Center, Charleston, SC (USA)

The teratogenic effect of ethanol in the C57BL/6J mouse can be attenuated by pretreatment with aspirin (ASA). One prominent effect of ASA is to inhibit prostaglandin (PGE) and thromboxane (TXB{sub 2}) production. We examined the effect in vivo ethanol exposure on PGE and TXB{sub 2} production in a uterine-embryo tissue sample of C57BL/6J mice either before or after in vivo ASA pretreatment on day 10 of gestation. Ethanol increase both PGE and TXB{sub 2} production by approximately 20%. ASA caused a marked reduction of PGE and TXB{sub 2} in both control and ethanol groups by approximately 80-90%. The mouse strain, gestation time, and study parameters used in this study were the same as in the previously reported ASA attenuation of the teratogenic effect of ethanol. Therefore, the present data add additional support to the hypothesis that prostaglandin and/or thromboxane production may be involved in at least some aspects of fetal alcohol syndrome.

• OSTI ID: 7136219
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 46:15; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLSALICYLIC ACID
ALCOHOLS
ANALGESICS
ANIMALS
ANTIPYRETICS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ETHANOL
FEMALE GENITALS
HYDROXY ACIDS
HYDROXY COMPOUNDS
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PREGNANCY
PROSTAGLANDINS
RODENTS
SYNTHESIS
TERATOGENESIS
UTERUS
VERTEBRATES