Effect of ethanol on thromboxane and prostacyclin synthesis by fetal platelets and umbilical artery
The effect of ethanol (10-500 mmol/1) on platelet thromboxane production and on vascular thromboxane and prostacyclin was studied in human fetal tissues. The release of thromboxane B/sub 2/ (a metabolite of thromboxane A/sub 2/) during thrombin-induced spontaneous aggregation of fetal platelets was inhibited by ethanol concentrations of 50 mmol/1 or higher. Ethanol at concentration from 100 mmol/1 also inhibited umbilical artery production of thromboxane B/sub 2/ and that of 6-keto-prostaglandin F/sub 1a/ (a metabolite of prostacyclin). However, it stimulated the conversion of exogenous arachidonic acid to thromboxane B/sub 2/ in fetal platelets and to 6-keto-prostaglandin F/sub 1a/ in the umbilical artery. This suggests that ethanol inhibits phospholipase A/sub 2/, but stimulates the enzymes distal from phospholipase A/sub 2/ in the prostaglandin-synthesizing enzyme cascade. 23 references, 2 figures, 1 table.
- Research Organization:
- Univ. of Helsinki, Finland
- OSTI ID:
- 5649296
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 41:3; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOXYLESTERASES
DATA
ENZYME ACTIVITY
ENZYMES
ESTERASES
ETHANOL
EXPERIMENTAL DATA
FETUSES
HYDROLASES
HYDROXY COMPOUNDS
INFORMATION
INHIBITION
LIPASE
MAMMALS
MAN
MATERIALS
NUMERICAL DATA
ORGANIC COMPOUNDS
PRIMATES
PROSTAGLANDINS
SYNTHESIS
TOXICITY
VERTEBRATES