Colonic blood flow in cat and man as analyzed by an inert gas washout technique

Journal Article · Thu Jan 01 00:00:00 EST 1976 · Gastroenterology; (United States)

OSTI ID:7120589

Hulten, L; Jodal, M; Lindhagen, J; Lundgren, O

An inert gas elimination technique for studying blood flow and flow distribution in the colon was developed on the cat and applied to patients during abdominal surgery. The method involves recording of the elimination of intra-arterially injected /sup 85/Kr from a colonic segment whereby the ..gamma..- and ..beta..-radiation of the tracer is registered simultaneously by a scintillation detector and Geiger-Muller tube, respectively. Total blood flow was determined from the recording of ..gamma..-radioactivity using a modification of Zierler's formula, and muscularis blood flow was calculated according to Kety from the mono-exponential elimination recorded by the Geiger-Muller tube. The relative weights of the muscularis and mucosa-submucosa were determined from dissections or histological sections. With these weights and total and muscularis blood flows, flow in the mucosa-submucosa was calculated. Total colonic blood flow was 18 +- 2 ml per min and 100 g of colonic tissue (mean +- SE; n equals 21). In the muscularis layer blood flow amounted to 11 +- 1 ml per min and 100 g of muscularis tissue (n = 12), and flow in the mucosa-submucosa was calculated to be 28 +- 5 ml per min and 100 g of mucosal-submucosal tissue. A major fraction (66 +- 6 percent) of total blood flow was distributed to the mucosa-submucosa. As total colonic blood flow was enhanced the increase in flow was diverted only to the mucosa-submucosa. The feline and human large bowel exhibited great qualitative and quantitative circulatory similarities.

• Research Organization: Univ. of Goteborg
• OSTI ID: 7120589
• Journal Information: Gastroenterology; (United States), Vol. 70:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD FLOW
MEASURING METHODS
LARGE INTESTINE
CATS
KRYPTON 85
MAN
WASHOUT
XENON 133
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON ISOTOPES
MAMMALS
NUCLEI
ORGANS
PRECIPITATION SCAVENGING
PRIMATES
RADIOISOTOPES
SEPARATION PROCESSES
VERTEBRATES
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics