Radiation-induced proctitis cystica profunda in the rat

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · Digestive Diseases and Sciences; (USA)

DOI:https://doi.org/10.1007/BF01536796· OSTI ID:6605110

Geisinger, K R; Scobey, M W; Northway, M G; Cassidy, K T; Castell, D O ^[1]

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1. Wake Forest Univ., Winston-Salem, NC (USA)

Therapeutic pelvic irradiation is notorious for the production of clinically significant sequela after a long latency. One of the rarest of these complications is proctitis cystica profunda (PCP). To study the histologic changes of chronic radiation proctitis, we evaluated 35 female Wistar rats that had received a single exposure of 22.5 Gy of radiation to the rectum and were then followed for one year. We identified PCP and its precursor lesions in 18 rats. The fully developed lesion consisted of a focal expansion of the submucosa by dilated cystic spaces lined by a single layer of benign epithelial cells. Usually, PCP evolved as glands herniated between small defects in the muscularis mucosae. Mitotic figures were not recognized in the cells lining the herniating glands. In two rats, the radiation had apparently caused large ulcers, which had subsequently reepithelialized, resulting in prominent submucosal glandular tissue. Although the number of goblet cells in the displaced epithelium was reduced, the cells had rather mature appearances ultrastructurally. Glands displaced into the submucosa were encased by an intact basal lamina but lacked in muscularis.

• OSTI ID: 6605110
• Journal Information: Digestive Diseases and Sciences; (USA), Journal Name: Digestive Diseases and Sciences; (USA) Vol. 35:7; ISSN 0163-2116; ISSN DDSCD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOSES
ELECTRON MICROSCOPY
EPITHELIUM
GASTROINTESTINAL TRACT
INJURIES
INTESTINES
LARGE INTESTINE
MAMMALS
MEDICINE
MEMBRANES
MICROSCOPY
MUCOUS MEMBRANES
NUCLEAR MEDICINE
ORGANS
PROCTITIS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RATS
RECTUM
RODENTS
SIDE EFFECTS
THERAPY
TISSUES
VERTEBRATES