Radiation proctitis in the rat. Sequential changes and effects of anti-inflammatory agents

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19881101)62:9<1962::AID-CNCR2820620916>3.0.CO;2-T· OSTI ID:6557392

Northway, M G; Scobey, M W; Geisinger, K R

Female Wistar rats were treated with single exposure irradiation to 2 cm of distal colon to cause radiation proctitis. All animals were evaluated by examination, colonoscopy and histologic evaluation for changes post-irradiation. Exposures of 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5 and 30 Gy caused dose-related clinical and histologic changes peaking at 7 to 15 days post-exposure. Rats treated with 20 Gy were colonoscoped and biopsied daily and showed sequential post-irradiation endoscopic changes ranging from mucosal edema and mild inflammatory changes to erosion and ulcers. Histologically, crypt abscess and mural wall necrosis similar to changes found in the human rectum after radiotherapy were noted. Treatment with nonsteroidal anti-inflammatory agents, (aspirin, indomethacin, piroxicam), misoprostol (a prostaglandin E1 analogue), or sucralfate (an anti-ulcer agent) did not ameliorate nor exacerbate radiation proctitis in rats exposed to 22.5 Gy. We conclude from these data that the female Wistar rat is a good model for studying radiation proctitis because endoscopic, histologic, and clinical changes seen post-exposure closely resemble those found in man.

• Research Organization: Bowman Gray School of Medicine of Wake Forest Univ., Winston-Salem, NC (USA)
• OSTI ID: 6557392
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 62:9; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
ANTIPYRETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GASTROINTESTINAL TRACT
INTESTINES
IRRADIATION
LARGE INTESTINE
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
PROCTITIS
RADIATION EFFECTS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RECTUM
RODENTS
VERTEBRATES