Piroxicam decreases postirradiation colonic neoplasia in the rat

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19901201)66:11<2300::AID-CNCR2820661108>3.0.CO;2-9· OSTI ID:6270571

Northway, M G; Scobey, M W; Cassidy, K T; Geisinger, K R ^[1]

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1. Wake Forest Univ., Winston Salem, NC (USA)

This study evaluated the effects of the nonsteroidal antiinflammatory agent piroxicam on chronic radiation proctitis in the rat. Forty female Wistar rats received a 2250-cGy dose of irradiation to the distal 2 cm of the colon. Twenty received piroxicam 8.0 mg/kg orally 30 minutes before exposure and 24 hours after exposure; 20 rats served as irradiated controls. All animals were evaluated by colonoscopy 1 and 3 weeks postexposure and every third week until death or killing at 1 year. At killing, colons were removed for light microscopic examination. One year postirradiation results showed no differences in mortality, vascular changes, acute inflammation, colitis cystica profunda, or rectal stricture between the control and piroxicam-treated groups. However, at 1 year postirradiation the control group demonstrated neoplasia in 15 of 19 animals compared with eight of 20 animals in the piroxicam-treated group. The first endoscopic appearance of colonic neoplasm occurred at 15 weeks postirradiation in one control irradiated rat whereas the first evidence of endoscopic neoplasm in the piroxicam-treated group did not occur until 36 weeks postirradiation. Histologic examination documented a tendency toward a greater presence of adenocarcinomas in the control group compared with the piroxicam-treated group. The authors conclude that piroxicam treatment significantly decreased the incidence of colonic neoplasia in general as well as delayed the endoscopic appearance of colonic neoplasia in rats after pelvic irradiation. 41 references.

• OSTI ID: 6270571
• Journal Information: Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 66:11; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIPYRETICS
BODY
CARCINOMAS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DISEASES
DRUGS
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
MAMMALS
NEOPLASMS
ORGANS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
VERTEBRATES