Esophageal blood flow in the cat. Normal distribution and effects of acid perfusion

Journal Article · Fri Feb 28 23:00:00 EST 1986 · Gastroenterology; (United States)

OSTI ID:5860516

Hollwarth, M E; Smith, M; Kvietys, P R; Granger, D N

The radioactive microsphere technique was used to estimate blood flow to different regions of the esophagus and to adjacent regions of the stomach before and after perfusion of the esophagus with hydrochloric acid (pH 1.5) for 5 min. Under resting conditions total blood flow, as well as blood flow to the mucosal-submucosal layer and the muscular layer, to both sphincters was significantly higher than to the esophageal body. Blood flow to the adjacent regions of the stomach was significantly higher than esophageal blood flow. Acid perfusion resulted in a large increase in total blood flow in both sphincters and the lower esophageal body. Gastric blood flow was not altered by acid perfusion. The esophageal hyperemia resulted primarily from an increase in blood flow to the muscular layer; mucosal-submucosal blood flow was increased only in the lower esophageal sphincter. The present study indicates that short periods (5 min) of gastroesophageal reflux may increase esophageal blood flow.

• Research Organization: Univ. of South Alabama, Mobile
• OSTI ID: 5860516
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 3; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD FLOW
BODY
BODY FLUIDS
CATS
DIGESTIVE SYSTEM
ESOPHAGUS
GASTRIC ACID
GASTROINTESTINAL TRACT
HYDROCHLORIC ACID
HYDROGEN COMPOUNDS
INORGANIC ACIDS
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
MICROSPHERES
ORGANS
STOMACH
TRACER TECHNIQUES
VERTEBRATES